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The Australian dingo is an early offshoot of modern breed dogs.
Field, Matt A; Yadav, Sonu; Dudchenko, Olga; Esvaran, Meera; Rosen, Benjamin D; Skvortsova, Ksenia; Edwards, Richard J; Keilwagen, Jens; Cochran, Blake J; Manandhar, Bikash; Bustamante, Sonia; Rasmussen, Jacob Agerbo; Melvin, Richard G; Chernoff, Barry; Omer, Arina; Colaric, Zane; Chan, Eva K F; Minoche, Andre E; Smith, Timothy P L; Gilbert, M Thomas P; Bogdanovic, Ozren; Zammit, Robert A; Thomas, Torsten; Aiden, Erez L; Ballard, J William O.
Affiliation
  • Field MA; Centre for Tropical Bioinformatics and Molecular Biology, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD 4878, Australia.
  • Yadav S; Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia.
  • Dudchenko O; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, High St, Kensington, NSW 2052, Australia.
  • Esvaran M; The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.
  • Rosen BD; Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA.
  • Skvortsova K; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
  • Edwards RJ; Animal Genomics and Improvement Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.
  • Keilwagen J; Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia.
  • Cochran BJ; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, High St, Kensington, NSW 2052, Australia.
  • Manandhar B; Julius Kühn-Institut, Erwin-Baur-Str. 27, 06484 Quedlinburg, Germany.
  • Bustamante S; School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
  • Rasmussen JA; School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
  • Melvin RG; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW 2052, Australia.
  • Chernoff B; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark.
  • Omer A; Center for Evolutionary Hologenomics, Faculty of Health and Medical Sciences, The GLOBE Institute University of Copenhagen, Copenhagen, Denmark.
  • Colaric Z; Department of Biomedical Sciences, University of Minnesota Medical School, 1035 University Drive, Duluth, MN 55812, USA.
  • Chan EKF; College of the Environment, Departments of Biology, and Earth and Environmental Sciences, Wesleyan University, Middletown, CT 06459, USA.
  • Minoche AE; The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.
  • Smith TPL; The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.
  • Gilbert MTP; Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia.
  • Bogdanovic O; Statewide Genomics, New South Wales Health Pathology, 45 Watt St, Newcastle, NSW 2300, Australia.
  • Zammit RA; Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia.
  • Thomas T; U.S. Meat Animal Research Center, Agricultural Research Service, USDA, Rd 313, Clay Center, NE 68933, USA.
  • Aiden EL; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark.
  • Ballard JWO; University Museum, NTNU, Trondheim, Norway.
Sci Adv ; 8(16): eabm5944, 2022 04 22.
Article in En | MEDLINE | ID: mdl-35452284
ABSTRACT
Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wolves / Canidae Limits: Animals Country/Region as subject: Oceania Language: En Journal: Sci Adv Year: 2022 Document type: Article Affiliation country: Australia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wolves / Canidae Limits: Animals Country/Region as subject: Oceania Language: En Journal: Sci Adv Year: 2022 Document type: Article Affiliation country: Australia