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Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.
Brunetti, Leonardo; Leuci, Rosalba; Carrieri, Antonio; Catto, Marco; Occhineri, Sara; Vinci, Giuseppe; Gambacorta, Lucia; Baltrukevich, Hanna; Chaves, Sílvia; Laghezza, Antonio; Altomare, Cosimo Damiano; Tortorella, Paolo; Santos, M Amélia; Loiodice, Fulvio; Piemontese, Luca.
Affiliation
  • Brunetti L; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy; Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lis
  • Leuci R; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Carrieri A; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Catto M; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Occhineri S; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Vinci G; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Gambacorta L; Institute of Science of Food Production-ISPA, Research National Council-CNR, Via Amendola, 122/O, 70126, Bari, Italy.
  • Baltrukevich H; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy; Faculty of Pharmacy, Chair of Technology and Biotechnology of Medical Remedies, Jagiellonian University Medical College in Krakow, Medyczna 9, 30-688, Kraków, Poland.
  • Chaves S; Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal.
  • Laghezza A; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Altomare CD; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Tortorella P; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Santos MA; Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal.
  • Loiodice F; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Piemontese L; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: luca.piemontese@uniba.it.
Eur J Med Chem ; 237: 114358, 2022 Jul 05.
Article in En | MEDLINE | ID: mdl-35462163
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Butyrylcholinesterase / Alzheimer Disease Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Country of publication: Francia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Butyrylcholinesterase / Alzheimer Disease Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Country of publication: Francia