Cascade of C(sp2)-H Addition to Carbonyl and C(sp2)-CN/C(sp2)-H Coupling Enabled by Brønsted Acid: Construction of Benzo[a]carbazole Frameworks.
Org Lett
; 24(17): 3232-3237, 2022 May 06.
Article
in En
| MEDLINE
| ID: mdl-35475641
ABSTRACT
Herein, we report an unprecedented cascade reaction of C(sp2)-H addition to carbonyl and the C(sp2)-CN/C(sp2)-H coupling of 2-(2-oxo-2-arylethyl)benzonitriles with indoles enabled by commercially available TsOH·H2O. The protocol represents the first metal-free C(sp2)-CN/C(sp2)-H coupling, affording a new route for the synthesis of various benzo[a]carbazole derivatives with a broad substrate scope, high yields, and simple conditions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2022
Document type:
Article