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Longibrachiamide A, a 20-Residue Peptaibol Isolated from Trichoderma longibrachiatum Rifai DMG-3-1-1.
Zhang, Shu-Hua; Yue, Xian-Lin; Zhao, Xue; Tang, Jing; Yang, Yu; Xu, Rui; Ma, Hao; Zhu, Shuai-Ming; Luo, Fu-Yao; Zhang, Qin; Zhang, Guo-Gang; Li, Chang-Wei.
Affiliation
  • Zhang SH; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
  • Yue XL; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 110016, Shenyang, China.
  • Zhao X; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
  • Tang J; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 110016, Shenyang, China.
  • Yang Y; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
  • Xu R; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
  • Ma H; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
  • Zhu SM; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
  • Luo FY; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
  • Zhang Q; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
  • Zhang GG; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
  • Li CW; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
Chem Biodivers ; 19(6): e202200286, 2022 Jun.
Article in En | MEDLINE | ID: mdl-35502602
ABSTRACT
Longibrachiamide A (1), a new 20-residue peptaibol, along with three known ones (2-4), were isolated from the fungus Trichoderma longibrachiatum Rifai DMG-3-1-1, isolated from a mushroom Clitocybe nebularis (Batsch) P. Kumm, which was collected from coniferous forest of northeast China in our previous work. The structure of longibrachiamide A (1) was determined by its NMR and ESI-MS/MS data, the absolute configuration of 1 was further determined by Marfey's analyses. And the complete NMR data of 2-4 were also reported for the first time. The similar CD spectra of 1-4 showed that they all had mixed 310 -/α-helical conformations. Compounds 1-4 showed strong cytotoxicities against BV2, A549 and MCF-7 cells, and also showed moderate inhibitory effects against the tested Gram-positive bacteria, including MRSA T144 and VRE-10.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trichoderma / Hypocreales Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trichoderma / Hypocreales Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Affiliation country: China