Host and viral non-coding RNAs in dengue pathogenesis.
Rev Med Virol
; 32(6): e2360, 2022 11.
Article
in En
| MEDLINE
| ID: mdl-35510480
ABSTRACT
Dengue virus (DENV) is a mosquito-borne flavivirus that causes frequent outbreaks in tropical countries. Due to the four different serotypes and ever-mutating RNA genome, it is challenging to develop efficient therapeutics. Early diagnosis is crucial to prevent the severe form of dengue, leading to mortality. In the past decade, rapid advancement in the high throughput sequencing technologies has shed light on the crucial regulating role of non-coding RNAs (ncRNAs), also known as the "dark matter" of the genome, in various pathological processes. In addition to the human host ncRNAs like microRNAs and circular RNAs, DENV also produces ncRNAs such as subgenomic flaviviral RNAs that can modulate the virus life cycle and regulate disease outcomes. This review outlines the advances in understanding the interplay between the human host and DENV ncRNAs, their regulation of the innate immune system of the host, and the prospects of the ncRNAs in clinical applications such as dengue diagnosis and promising therapeutics.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dengue
/
Dengue Virus
/
MicroRNAs
/
Flavivirus
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Screening_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Rev Med Virol
Journal subject:
VIROLOGIA
Year:
2022
Document type:
Article
Affiliation country:
India