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Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic.
Li, Dongxu; Yu, Xufen; Kottur, Jithesh; Gong, Weida; Zhang, Zhao; Storey, Aaron J; Tsai, Yi-Hsuan; Uryu, Hidetaka; Shen, Yudao; Byrum, Stephanie D; Edmondson, Rick D; Mackintosh, Samuel G; Cai, Ling; Liu, Zhijie; Aggarwal, Aneel K; Tackett, Alan J; Liu, Jing; Jin, Jian; Wang, Gang Greg.
Affiliation
  • Li D; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Yu X; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Kottur J; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gong W; Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Zhang Z; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Storey AJ; Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Tsai YH; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Uryu H; Department of Molecular Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Shen Y; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Byrum SD; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Edmondson RD; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Mackintosh SG; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Cai L; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Liu Z; Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Aggarwal AK; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Tackett AJ; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Liu J; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Jin J; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Wang GG; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Oncogene ; 41(24): 3328-3340, 2022 06.
Article in En | MEDLINE | ID: mdl-35525905
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Intracellular Signaling Peptides and Proteins / Ikaros Transcription Factor Limits: Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2022 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Intracellular Signaling Peptides and Proteins / Ikaros Transcription Factor Limits: Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2022 Document type: Article Affiliation country: Estados Unidos