Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast proliferation by regulating the WWP2/Notch1 axis.
Regen Med
; 17(6): 375-388, 2022 06.
Article
in En
| MEDLINE
| ID: mdl-35545948
Acute ocular chemical burns are ophthalmic emergencies which require immediate diagnosis and treatment. Quiescent corneal cells differentiate into active fibroblast and myofibroblast phenotypes after corneal injury. Mesenchymal stem cells (MSCs) under hypoxia treatment are applied for the treatment of acute ocular chemical burns. We aimed to explore the role of hypoxic MSCs in corneal alkali burns and the underlying mechanism. The result showed that hypoxic MSCs reduced the proliferation of rat corneal fibroblasts, implying an anti-inflammatory effect. In vivo, treatment with hypoxic MSCs decreased the corneal neovascularization scores and opacity scores, indicating a protective effect on corneal alkali burns. We concluded that hypoxic MSCs could alleviate corneal injury in alkali burns and may be a promising therapeutic option for corneal alkali burns.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Burns, Chemical
/
Ubiquitin-Protein Ligases
/
Mesenchymal Stem Cell Transplantation
/
Receptor, Notch1
/
Mesenchymal Stem Cells
/
Corneal Injuries
/
Hypoxia
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Regen Med
Year:
2022
Document type:
Article
Affiliation country:
China