Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1.

Buel, Gwen R; Dang, Huy Q; Asara, John M; Blenis, John; Mutvei, Anders P

Buel, Gwen R; Dang, Huy Q; Asara, John M; Blenis, John; Mutvei, Anders P.

Affiliation

Buel GR; Programs in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA; Meyer Cancer Center and Department of Pharmacology, Weill Cornell Medical College, New York, New York, USA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Dang HQ; Department of Immunology, Pathology and Genetics, Uppsala University, Uppsala, Sweden.
Asara JM; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Blenis J; Meyer Cancer Center and Department of Pharmacology, Weill Cornell Medical College, New York, New York, USA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: jblenis@med.cornell.edu.
Mutvei AP; Department of Immunology, Pathology and Genetics, Uppsala University, Uppsala, Sweden. Electronic address: anders.mutvei@igp.uu.se.

J Biol Chem ; 298(6): 102030, 2022 06.

Article in En | MEDLINE | ID: mdl-35577075

Subject(s)
Key words

Akt; amino acid; mTORC1; signaling; starvation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Mechanistic Target of Rapamycin Complex 1 Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2022 Document type: Article Affiliation country: Estados Unidos

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