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Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Parcella, Kyle; Patel, Manoj; Tu, Yong; Eastman, Kyle; Peese, Kevin; Gillis, Eric; Belema, Makonen; Dicker, Ira B; McAuliffe, Brian; Ding, Bo; Falk, Paul; Simmermacher, Jean; Parker, Dawn D; Sivaprakasam, Prasanna; Khan, Javed A; Kish, Kevin; Lewis, Hal; Hanumegowda, Umesh; Jenkins, Susan; Kadow, John F; Krystal, Mark; Meanwell, Nicholas A; Naidu, B Narasimhulu.
Affiliation
  • Parcella K; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA. Electronic address: kyle.e.parcella@viivhealthcare.com.
  • Patel M; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Tu Y; Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, NJ 08543-4000, USA(1).
  • Eastman K; Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, NJ 08543-4000, USA(1).
  • Peese K; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Gillis E; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Belema M; Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, NJ 08543-4000, USA(1).
  • Dicker IB; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • McAuliffe B; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Ding B; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Falk P; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Simmermacher J; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Parker DD; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Sivaprakasam P; Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, NJ 08543-4000, USA(1).
  • Khan JA; Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, NJ 08543-4000, USA(1).
  • Kish K; Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, NJ 08543-4000, USA(1).
  • Lewis H; Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, NJ 08543-4000, USA(1).
  • Hanumegowda U; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Jenkins S; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Kadow JF; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Krystal M; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
  • Meanwell NA; Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, NJ 08543-4000, USA(1).
  • Naidu BN; ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.
Bioorg Med Chem ; 67: 116833, 2022 08 01.
Article in En | MEDLINE | ID: mdl-35605346

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / HIV Integrase Inhibitors / HIV Integrase / Anti-HIV Agents Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / HIV Integrase Inhibitors / HIV Integrase / Anti-HIV Agents Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Country of publication: Reino Unido