Supercomplex supercomplexes: Raison d'etre and functional significance of supramolecular organization in oxidative phosphorylation.
Biomol Concepts
; 13(1): 272-288, 2022 May 26.
Article
in En
| MEDLINE
| ID: mdl-35617665
Key words
2,4-dinitrophenol; Alzheimer's disease; Complexes IV; Gunnar Hollunger's pioneering work in pharmacology; Mitchell's single-ion chemiosmotic theory; Nath's torsional mechanism of energy transduction and ATP synthesis; Nath's two-ion theory of energy coupling; OXPHOS supercomplexes; Paolo Bernardi's pioneering work on cell death and ATP; alkylguanidines; carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; competitive inhibition of succinate with the anionic uncouplers of OXPHOS; coupling of proton and succinate anion transport; dicoumarol; differential release of inhibition by pharmacological agents by uncouplers; functional role of the OXPHOS supercomplexes; inhibition of succinate entry by uncouplers; integrated mitochondrial function; interaction of site-specific guanidine derivatives with mitochondria; mitochondrial dysfunction; new definition of mitochondrial respiration; new model of energy transfer in mitochondria; octylguanidines; oxidative phosphorylation; phenethylbiguanides; sensing of local electrical potential, Δψ; supramolecular biology; supramolecular chemistry; translocation of succinate monoanions and succinate dianions across cristae membranes; two distinct energy conservation pathways between the electron transport chain and FOF1-ATP synthase; type 2 diabetes
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxidative Phosphorylation
/
Diabetes Mellitus, Type 2
Limits:
Animals
Language:
En
Journal:
Biomol Concepts
Year:
2022
Document type:
Article
Affiliation country:
India
Country of publication:
Alemania