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Usefulness of high-risk HPV early oncoprotein (E6 and E7) serological markers in the detection of cervical cancer: A systematic review and meta-analysis.
Singini, Mwiza Gideon; Singh, Elvira; Bradshaw, Debbie; Ramaliba, Thendo; Chen, Wenlong Carl; Motlhale, Melitah; Kamiza, Abram Bunya; Babb de Villiers, Chantal; Muchengeti, Mazvita; Mathew, Christopher G; Newton, Robert; Bender, Noemi; Waterboer, Tim; Sitas, Freddy.
Affiliation
  • Singini MG; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
  • Singh E; Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Bradshaw D; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
  • Ramaliba T; Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Chen WC; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
  • Motlhale M; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
  • Kamiza AB; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
  • Babb de Villiers C; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Muchengeti M; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
  • Mathew CG; Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Newton R; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Bender N; Division of Human Genetics, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Waterboer T; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
  • Sitas F; Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
J Med Virol ; 95(1): e27900, 2023 01.
Article in En | MEDLINE | ID: mdl-35641882
ABSTRACT
We reviewed the literature on the importance of selected anti-high-risk human papillomavirus (HR-HPV) antibodies (namely, 16/18 and early oncoproteins E6 and E7) as potential serological markers for early detection of individuals at high risk of cervical cancer. We searched for studies in PubMed and Embase databases published from 2010 to 2020 on antibodies against HR-HPV E6 and E7 early proteins and cervical cancer. Pooled sensitivity and specificity for HPV16 and HPV18 antibodies were calculated using a bivariate hierarchical random-effects model. A total of 69 articles were identified; we included three studies with 1550 participants. For the three HPV16/18 E6 and E7 antibody tests, enzyme-linked immunosorbent assay-based assays had a sensitivity of 18% for detecting CIN2+ (95% confidence interval [CI] 15-21) and a specificity of 96% (95% CI 92-98), for slot-blot, sensitivity was 28.9% (95% CI 23.3-35.1) and specificity was 72% (95% CI 66.6-77.0) for detecting CIN2+, and for multiplex HPV serology assay based on a glutathione S-transferase, sensitivity was 16% (95% CI 8.45-28.6) and specificity was 98% (95% CI 97-99) for detecting invasive cervical cancer. HR-HPV16/18 E6 and E7 serological markers showed high specificity, but sensitivity was suboptimal for the detection of cervical cancer in either population screening settings or as point-of-care screening tests.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Oncogene Proteins, Viral / Papillomavirus Infections Type of study: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies / Systematic_reviews Limits: Female / Humans Language: En Journal: J Med Virol Year: 2023 Document type: Article Affiliation country: Sudáfrica

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Oncogene Proteins, Viral / Papillomavirus Infections Type of study: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies / Systematic_reviews Limits: Female / Humans Language: En Journal: J Med Virol Year: 2023 Document type: Article Affiliation country: Sudáfrica