Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis.
Acta Pharm Sin B
; 12(5): 2280-2299, 2022 May.
Article
in En
| MEDLINE
| ID: mdl-35646539
ATG5, autophagy-related 5; Acetyl-H3, acetyl-histone 3; Atherosclerosis; Autophagy; BET, bromodomain and extra-terminal; BRD4; BRD4, bromodomain protein 4; CQ, chloroquine; CVDs, cardiovascular diseases; ChIP, chromatin immunoprecipitation; Cur, curcumin; Curcumin; Dil-ox-LDL, 1,1'-dioctadecyl-3,3,3',3'-tetramethy-lindocarbocyanine perchlorate labeled oxidized low-density lipoprotein; FCs, foam cells; HFD, high-fat diet; IL-1ß, interleukin 1ß; Inflammation; LIR, LC3-interacting region; MCP-1, monocyte chemotactic protein 1; Macrophage; NAC, N-acetyl-l-cysteine; ORO, Oil red O; P300; ROS, reactive oxygen species; Re-ChIP, re-chromatin immunoprecipitation; SE, super-enhancer; TFEB; TFEB, transcription factor EB; TNF-α, tumor necrosis factor α; mTORC1, mammalian target of rapamycin complex 1; ox-LDL, oxidized low-density lipoprotein; qRT-PCR, quantitative real-time polymerase chain reaction; siRNAs, small interference RNAs
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
Language:
En
Journal:
Acta Pharm Sin B
Year:
2022
Document type:
Article
Affiliation country:
China
Country of publication:
Países Bajos