Use of biologics to treat relapsing and/or refractory polyarteritis nodosa: data from a European collaborative study.
Rheumatology (Oxford)
; 62(1): 341-346, 2022 12 23.
Article
in En
| MEDLINE
| ID: mdl-35686919
ABSTRACT
OBJECTIVES:
To describe the effectiveness and safety of biologics for the treatment of relapsing and/or refractory polyarteritis nodosa (PAN).METHODS:
A retrospective European collaborative study was conducted in patients with PAN who received biologics for relapsing and/or refractory disease.RESULTS:
Forty-two patients with PAN received a total of 53 biologic courses, including TNF-α blockers in 15 cases, rituximab (RTX) in 18 cases, tocilizumab (TCZ) in 10 cases and other biologics in 10 cases. TNF-α blockers and TCZ were mainly used for refractory diseases whereas RTX was mainly initiated for relapsing disease. After a median follow-up of 29 (8-50) months, remission, partial response, treatment failure and treatment discontinuation due to severe adverse events occurred in, respectively, 40%, 13%, 40% and 7% of patients receiving TNF-α blockers, 50%, none, 30% and 20% of TCZ recipients, and 33%, 11%, 56% and none of the RTX recipients. No remission was noted in patients treated with other biologics. Severe adverse events were observed in 14 (28%) patients without significant differences between the three biologics, leading to early biologics discontinuation in only three cases.CONCLUSION:
These results suggest that TCZ may be effective in relapsing and/or refractory PAN. Our data warrant further study to confirm these findings.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyarteritis Nodosa
/
Arthritis, Rheumatoid
/
Biological Products
/
Antirheumatic Agents
Limits:
Humans
Language:
En
Journal:
Rheumatology (Oxford)
Journal subject:
REUMATOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Francia