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Three new hasubanan-type alkaloids from the Stephania longa.
Lin, Rong-Xiao; Fan, Lixia; Chen, Xin; Wu, Jundi; Liu, Zheng; Liu, Fang; Yang, An-Ping; Xia, Chenglai; Liu, Hui; Chen, Hong-Yuan.
Affiliation
  • Lin RX; Department of Pathogenic Biology and Immunology, School of Life Sciences and Biopharmaceuticals, Guangdong Pharmaceutical University, Guangzhou, P.R. China.
  • Fan L; School of Medicine, Foshan University, Foshan, P.R. China.
  • Chen X; School of Medicine, Foshan University, Foshan, P.R. China.
  • Wu J; School of Medicine, Foshan University, Foshan, P.R. China.
  • Liu Z; School of Medicine, Foshan University, Foshan, P.R. China.
  • Liu F; School of Medicine, Foshan University, Foshan, P.R. China.
  • Yang AP; School of Medicine, Foshan University, Foshan, P.R. China.
  • Xia C; School of Medicine, Foshan University, Foshan, P.R. China.
  • Liu H; Affiliated Foshan Maternity and Child Healthcare Hospital, Southern Medical University, Foshan, P.R. China.
  • Chen HY; School of Medicine, Foshan University, Foshan, P.R. China.
Nat Prod Res ; 37(20): 3543-3549, 2023.
Article in En | MEDLINE | ID: mdl-35695116
ABSTRACT
Three new hasubanan-type alkaloids, stephalonine Q (1), stephalonine R (2) and stephalonine S (3), together with four known alkaloids, isolonganone (4), eletefine (5), aurantiamide (6), N-cinnamoyltyramine (7), were isolated from the whole plant of Stephania longa. Their structures were identified by NMR, HR-ESI-MS, CD methods and x-ray crystallography, as well as by comparison with the literature data. All isolated compounds were evaluated for their antimicrobial activities against five bacteria in vitro. Compound 5 displayed inhibitory activity against only S. aureus, with an MIC value of 50 µg/mL.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Nat Prod Res Year: 2023 Document type: Article
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Nat Prod Res Year: 2023 Document type: Article