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Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase.
Sun, Yaoliang; Zhang, Ying; Chen, Xiaoai; Yu, Aisong; Du, Wenhao; Huang, Yuting; Wu, Feifei; Yu, Lei; Li, Jiayi; Wen, Cuiyun; Yang, Hong; Shi, Qiongyu; Geng, Meiyu; Huang, Xun; Xu, Shilin.
Affiliation
  • Sun Y; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 ZuChongZhi Road, Shanghai, 201203, PR China.
  • Zhang Y; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, NO. 19A Yuquan Road, Beijing, 100049, PR China.
  • Chen X; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing, 210023, PR China.
  • Yu A; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, NO. 19A Yuquan Road, Beijing, 100049, PR China.
  • Du W; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing, 210023, PR China.
  • Huang Y; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, NO. 19A Yuquan Road, Beijing, 100049, PR China.
  • Wu F; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 ZuChongZhi Road, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, NO. 19A Yuquan Road, Beijing, 100049, PR China.
  • Yu L; Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
  • Li J; Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, PR China.
  • Wen C; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 ZuChongZhi Road, Shanghai, 201203, PR China.
  • Yang H; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, PR China; Lingang Laboratory, Shanghai, 200210, PR China.
  • Shi Q; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, PR China; Lingang Laboratory, Shanghai, 200210, PR China.
  • Geng M; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, NO. 19A Yuquan Road, Beijing, 100049, PR China; Hangzhou Institute
  • Huang X; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, NO. 19A Yuquan Road, Beijing, 100049, PR China; Hangzhou Institute
  • Xu S; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 ZuChongZhi Road, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, NO. 19A Yuquan Road, Beijing, 100049, PR China; School of Chinese M
Eur J Med Chem ; 239: 114528, 2022 Sep 05.
Article in En | MEDLINE | ID: mdl-35717870
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone Methyltransferases / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Country of publication: Francia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone Methyltransferases / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Country of publication: Francia