New Targets for Extracorporeal Blood Purification Therapies in Sepsis.
Blood Purif
; 52(1): 1-7, 2023.
Article
in En
| MEDLINE
| ID: mdl-35717943
ABSTRACT
As highlighted by the last international consensus definition for sepsis and septic shock (sepsis-3), sepsis comes from a complex relationship between a pathogen and a dysregulated host response. To date, the treatment of sepsis is based on antimicrobial treatment, source control, and organ support. Extracorporeal blood purification therapies have been proposed as adjuvant therapies to modulate the dysregulated inflammatory response. These therapies aim mostly at removing inflammatory mediators (cytokines) and endotoxins from the blood. However, so far, they failed to clearly demonstrate an improvement in patient survival when evaluated in randomized trials. Recently, new devices directly targeting the primary determinants of sepsis, e.g., the pathogen itself and the host immune cells, have been developed. This short review aimed at presenting new blood purification devices that have recently been developed to target pathogens and immune cells. For each, we will present the mechanism of action of the therapy and discuss the related literature.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Shock, Septic
/
Hemofiltration
/
Sepsis
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Blood Purif
Year:
2023
Document type:
Article
Affiliation country:
Francia