Microbiome-Immune Interactions in Allergy and Asthma.
J Allergy Clin Immunol Pract
; 10(9): 2244-2251, 2022 09.
Article
in En
| MEDLINE
| ID: mdl-35724951
ABSTRACT
The human microbiota has been established as a key regulator of host health, in large part owing to its constant interaction with and impact on host immunity. A range of environmental exposures spanning from the prenatal period through adulthood are known to affect the composition and molecular productivity of microbiomes across mucosal and dermal tissues with short- and long-term consequences for host immune function. Here we review recent findings in the field that provide insights into how microbial-immune interactions promote and sustain immune dysfunction associated with allergy and asthma. We consider both early life microbiome perturbation and the molecular underpinnings of immune dysfunction associated with subsequent allergy and asthma development in childhood, as well as microbiome features that relate to phenotypic attributes of allergy and asthma in older patients with established disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Microbiota
/
Hypersensitivity
Limits:
Adult
/
Aged
/
Humans
Language:
En
Journal:
J Allergy Clin Immunol Pract
Year:
2022
Document type:
Article