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Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle.
Romero, Matthew A; Mumford, Petey W; Roberson, Paul A; Osburn, Shelby C; Young, Kaelin C; Sedivy, John M; Roberts, Michael D.
Affiliation
  • Romero MA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA.
  • Mumford PW; Department of Exercise Science, Lindenwood University, St. Charles, MO.
  • Roberson PA; Department of Cellular and Molecular Physiology, College of Medicine, The Pennsylvania State University, Hershey, PA.
  • Osburn SC; School of Kinesiology, Auburn University, Auburn, AL.
  • Sedivy JM; Department of Molecular, Cellular Biology and Biochemistry, Center on the Biology of Aging, Brown University, Providence, RI.
Exerc Sport Sci Rev ; 50(4): 185-193, 2022 10 01.
Article in En | MEDLINE | ID: mdl-35749745
Retrotransposons are gene segments that proliferate in the genome, and the Long INterspersed Element 1 (LINE-1 or L1) retrotransposon is active in humans. Although older mammals show enhanced skeletal muscle L1 expression, exercise generally reverses this trend. We hypothesize skeletal muscle L1 expression influences muscle physiology, and additional innovative investigations are needed to confirm this hypothesis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Long Interspersed Nucleotide Elements Limits: Animals / Humans Language: En Journal: Exerc Sport Sci Rev Year: 2022 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Long Interspersed Nucleotide Elements Limits: Animals / Humans Language: En Journal: Exerc Sport Sci Rev Year: 2022 Document type: Article Country of publication: Estados Unidos