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The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.
Nehme, Ralda; Pietiläinen, Olli; Artomov, Mykyta; Tegtmeyer, Matthew; Valakh, Vera; Lehtonen, Leevi; Bell, Christina; Singh, Tarjinder; Trehan, Aditi; Sherwood, John; Manning, Danielle; Peirent, Emily; Malik, Rhea; Guss, Ellen J; Hawes, Derek; Beccard, Amanda; Bara, Anne M; Hazelbaker, Dane Z; Zuccaro, Emanuela; Genovese, Giulio; Loboda, Alexander A; Neumann, Anna; Lilliehook, Christina; Kuismin, Outi; Hamalainen, Eija; Kurki, Mitja; Hultman, Christina M; Kähler, Anna K; Paulo, Joao A; Ganna, Andrea; Madison, Jon; Cohen, Bruce; McPhie, Donna; Adolfsson, Rolf; Perlis, Roy; Dolmetsch, Ricardo; Farhi, Samouil; McCarroll, Steven; Hyman, Steven; Neale, Ben; Barrett, Lindy E; Harper, Wade; Palotie, Aarno; Daly, Mark; Eggan, Kevin.
Affiliation
  • Nehme R; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. rnehme@broadinstitute.org.
  • Pietiläinen O; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA. rnehme@broadinstitute.org.
  • Artomov M; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. ollip@broadinstitute.org.
  • Tegtmeyer M; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA. ollip@broadinstitute.org.
  • Valakh V; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Lehtonen L; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Bell C; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Singh T; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Trehan A; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Sherwood J; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Manning D; Institute for Molecular Medicine Finland, University of Helsinki, FI-00014, Helsinki, Finland.
  • Peirent E; Department of Cell Biology, Blavatnik Institute of Harvard Medical School, Boston, MA, USA.
  • Malik R; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Guss EJ; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Hawes D; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Beccard A; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Bara AM; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Hazelbaker DZ; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Zuccaro E; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Genovese G; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Loboda AA; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Neumann A; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Lilliehook C; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Kuismin O; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Hamalainen E; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Kurki M; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Hultman CM; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Kähler AK; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Paulo JA; Department of Stem Cell and Regenerative Biology, and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Ganna A; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Madison J; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Cohen B; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • McPhie D; ITMO University, St. Petersburg, Russia.
  • Adolfsson R; Almazov National Medical Research Centre, Saint-Petersburg, Russia.
  • Perlis R; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Dolmetsch R; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Farhi S; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • McCarroll S; PEDEGO Research Unit, University of Oulu, FI-90014, Oulu, Finland.
  • Hyman S; Medical Research Center, Oulu University Hospital, FI-90014, Oulu, Finland.
  • Neale B; Department of Clinical Genetics, Oulu University Hospital, 90220, Oulu, Finland.
  • Barrett LE; Institute for Molecular Medicine Finland, University of Helsinki, FI-00014, Helsinki, Finland.
  • Harper W; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Palotie A; Institute for Molecular Medicine Finland, University of Helsinki, FI-00014, Helsinki, Finland.
  • Daly M; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Eggan K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
Nat Commun ; 13(1): 3690, 2022 06 27.
Article in En | MEDLINE | ID: mdl-35760976

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / DiGeorge Syndrome / Induced Pluripotent Stem Cells Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / DiGeorge Syndrome / Induced Pluripotent Stem Cells Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: Estados Unidos