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Regulation of TORC1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E Brain Tumor Models.
Li, Fuyang; Bondra, Kathryn M; Ghilu, Samson; Studebaker, Adam; Liu, Qianqian; Michalek, Joel E; Kogiso, Mari; Li, Xiao-Nan; Kalapurakal, John A; James, C David; Burma, Sandeep; Kurmasheva, Raushan T; Houghton, Peter J.
Affiliation
  • Li F; Greehey Children's Cancer Research Institute, UT Health, San Antonio, Texas.
  • Bondra KM; Greehey Children's Cancer Research Institute, UT Health, San Antonio, Texas.
  • Ghilu S; Greehey Children's Cancer Research Institute, UT Health, San Antonio, Texas.
  • Studebaker A; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, Ohio.
  • Liu Q; Department of Epidemiology and Biostatistics, UT Health, San Antonio, Texas.
  • Michalek JE; Department of Epidemiology and Biostatistics, UT Health, San Antonio, Texas.
  • Kogiso M; Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Houston, Texas.
  • Li XN; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Kalapurakal JA; Department of Radiation Oncology and Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • James CD; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Burma S; Department of Neurosurgery, UT Health, San Antonio, Texas.
  • Kurmasheva RT; Department of Biochemistry and Structural Biology, UT Health, San Antonio, Texas.
  • Houghton PJ; Greehey Children's Cancer Research Institute, UT Health, San Antonio, Texas.
Clin Cancer Res ; 28(17): 3836-3849, 2022 09 01.
Article in En | MEDLINE | ID: mdl-35797217
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Pyrimidinones / Brain Neoplasms / Mechanistic Target of Rapamycin Complex 1 / Glioma Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2022 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Pyrimidinones / Brain Neoplasms / Mechanistic Target of Rapamycin Complex 1 / Glioma Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2022 Document type: Article Country of publication: Estados Unidos