Association between sarcoidosis and cardiovascular Outcomes: A systematic review and Meta-analysis.
Int J Cardiol Heart Vasc
; 41: 101073, 2022 Aug.
Article
in En
| MEDLINE
| ID: mdl-35800042
ABSTRACT
Background:
Sarcoidosis is a chronic inflammatory disorder of unknown etiology associated with high morbidity and mortality. Its association with cardiovascular outcomes is under-documented.Aim:
The aim of this study was to assess the adverse cardiovascular outcomes in patients with sarcoidosis compared with that of non-sarcoidosis.Methodology:
Online databases including PubMed, Embase and Scopus were queried from inception until March 2022. The outcomes assessed included all-cause mortality (ACM) and incidence of ventricular tachycardia (VT), heart failure (HF) and atrial arrhythmias (AA).Result:
A total of 6 studies with 22,539,096 participants (42,763 Sarcoidosis, 22,496,354 Non-Sarcoidosis) were included in this analysis. The pooled prevalence of sarcoidosis was 13.1% (95% CI 1% to 70%). The overall mean age was 47 years. The most common comorbidities were hypertension (12.7% vs 12.5%), and diabetes mellitus (5.5% vs 4%) respectively. The pooled analysis of primary endpoints showed that all-cause mortality (RR, 2.08; 95% CI 1.17 to 3.08; p = 0.01) was significantly increased in sarcoidosis patients. The pooled analysis of secondary endpoints showed that the incidence of VT (RR, 15.3; 95% CI 5.39 to 43.42); p < 0.001), HF (RR, 4.96; 95% CI 2.02 to 12.14; p < 0.001) and AA (RR, 2.55; 95% CI 1.47 to 4.44); p = 0.01) were significantly higher with sarcoidosis respectively compared to non-sarcoidosis.Conclusion:
Incidence of VT, HF and AA was significantly higher in patients with CS. Clinicians should be aware of these adverse cardiovascular events associated with sarcoidosis.
AA, Atrial Arrhythmia; ACM, All-cause mortality; ACS, Acute coronary syndrome; Atrial Arrhythmia; CS, Cardiac Sarcoidosis; Cardiovascular outcomes; HF, Heart failure; Heart Failure; ICD, Implantable Cardioverter Defibrillator; MI, Myocardial infarction; Mortality; NA, Not available; NS, Non-Sarcoidosis; OR, Odds ratio; Pathology; RCT, Randomized Controlled Trial; Sarcoidosis; VT, Ventricular Tachycardia; Ventricular Arrhythmia
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Risk_factors_studies
/
Systematic_reviews
Language:
En
Journal:
Int J Cardiol Heart Vasc
Year:
2022
Document type:
Article
Affiliation country:
Filipinas