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40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat.
Yang, Xiaoyu; Li, Xuepei; Yuan, Yikai; Sun, Tong; Yang, Jingguo; Deng, Bo; Yu, Hang; Gao, Anliang; Guan, Junwen.
Affiliation
  • Yang X; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
  • Li X; Medical Simulation Center, Chengdu First People's Hospital, Chengdu, China.
  • Yuan Y; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
  • Sun T; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
  • Yang J; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
  • Deng B; College of Electronic Engineering (College of Meteorological Observation), Chengdu University of Information Technology, Chengdu, China.
  • Yu H; College of Electronic Engineering (College of Meteorological Observation), Chengdu University of Information Technology, Chengdu, China.
  • Gao A; Department of Neurosurgery, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.
  • Guan J; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Front Neurol ; 13: 882991, 2022.
Article in En | MEDLINE | ID: mdl-35800078
Background: Photobiomodulation (PBM) using low-level light-emitting diodes (LEDs) can be rapidly applied to various neurological disorders safely and non-invasively. Materials and Methods: Forty-eight rats were involved in this study. The traumatic brain injury (TBI) model of rat was set up by a controlled cortical impact (CCI) injury. An 8-channel cortex electrode EEG was fixed to two hemispheres, and gamma oscillations were extracted according to each electrode. A 40 hz blue LED stimulation was set at four points of the frontal and parietal regions for 60 s each, six times per day for 1 week. Modified Neurologic Severity Scores (mNSS) were used to evaluate the level of neurological function. Results: In the right-side TBI model, the gamma oscillation decreased in electrodes Fp2, T4, C4, and O2; but significantly increased after 1 week of 40 hz Blue LED intervention. In the left-side TBI model, the gamma oscillation decreased in electrodes Fp1, T3, C3, and O1; and similarly increased after 1 week of 40 hz Blue LED intervention. Both left and right side TBI rats performed significantly better in mNSS after 40 hz Blue LED intervention. Conclusion: TBI causes the decrease of gamma oscillations on the injured side of the brain of rats. The 40 hz Blue LED therapy could relieve the gamma oscillation changes caused by TBI and improve the prognosis of TBI.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Neurol Year: 2022 Document type: Article Affiliation country: China Country of publication: Suiza

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Neurol Year: 2022 Document type: Article Affiliation country: China Country of publication: Suiza