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Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
Ladduwahetty, Tammy; Lee, Matthew R; Maillard, Michel C; Cachope, Roger; Todd, Daniel; Barnes, Michael; Beaumont, Vahri; Chauhan, Alka; Gallati, Caroline; Haughan, Alan F; Kempf, Georg; Luckhurst, Christopher A; Matthews, Kim; McAllister, George; Mitchell, Philip; Patel, Hiral; Rose, Mark; Saville-Stones, Elizabeth; Steinbacher, Stefan; Stott, Andrew J; Thatcher, Emma; Tierney, Jason; Urbonas, Liudvikas; Munoz-Sanjuan, Ignacio; Dominguez, Celia.
Affiliation
  • Ladduwahetty T; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Lee MR; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Maillard MC; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Cachope R; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Todd D; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Barnes M; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Beaumont V; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Chauhan A; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Gallati C; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Haughan AF; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Kempf G; Proteros Biostructures GmbH, Bunsenstr. 7a, D-82152 Planegg-Martinsried, Germany.
  • Luckhurst CA; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Matthews K; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • McAllister G; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Mitchell P; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Patel H; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Rose M; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Saville-Stones E; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Steinbacher S; Proteros Biostructures GmbH, Bunsenstr. 7a, D-82152 Planegg-Martinsried, Germany.
  • Stott AJ; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Thatcher E; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Tierney J; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Urbonas L; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Munoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
J Med Chem ; 65(14): 9819-9845, 2022 07 28.
Article in En | MEDLINE | ID: mdl-35816678
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Huntington Disease Type of study: Diagnostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Huntington Disease Type of study: Diagnostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Reino Unido