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Amygdala subnuclei volumes and anxiety behaviors in children and adolescents with autism spectrum disorder, attention deficit hyperactivity disorder, and obsessive-compulsive disorder.
Seguin, Diane; Pac, Sara; Wang, Jianan; Nicolson, Rob; Martinez-Trujillo, Julio; Anagnostou, Evdokia; Lerch, Jason P; Hammill, Christopher; Schachar, Russell; Crosbie, Jennifer; Kelley, Elizabeth; Ayub, Muhammad; Brian, Jessica; Liu, Xudong; Arnold, Paul D; Georgiades, Stelios; Duerden, Emma G.
Affiliation
  • Seguin D; Physiology & Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Canada.
  • Pac S; Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, Canada.
  • Wang J; Biomedical Engineering, Faculty of Engineering, Western University, London, Canada.
  • Nicolson R; Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
  • Martinez-Trujillo J; Physiology & Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Canada.
  • Anagnostou E; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, Toronto, Canada.
  • Lerch JP; The Hospital for Sick Children, Toronto, Canada.
  • Hammill C; Wellcome Centre for Integrative Neuroimaging, University of Oxford, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford, UK.
  • Schachar R; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
  • Crosbie J; The Hospital for Sick Children, Toronto, Canada.
  • Kelley E; The Hospital for Sick Children, Toronto, Canada.
  • Ayub M; The Hospital for Sick Children, Toronto, Canada.
  • Brian J; Department of Psychology, Queen's University, Kingston, Canada.
  • Liu X; Department of Psychiatry, Queen's University, Kingston, Canada.
  • Arnold PD; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, Toronto, Canada.
  • Georgiades S; Department of Psychiatry, Queen's University, Kingston, Canada.
  • Duerden EG; Queen's Genomics Lab at Ongwanada (QGLO), Ongwanada Resource Center, Kingston, Canada.
Hum Brain Mapp ; 43(16): 4805-4816, 2022 11.
Article in En | MEDLINE | ID: mdl-35819018
Alterations in the structural maturation of the amygdala subnuclei volumes are associated with anxiety behaviors in adults and children with neurodevelopmental and associated disorders. This study investigated the relationship between amygdala subnuclei volumes and anxiety in 233 children and adolescents (mean age = 11.02 years; standard deviation = 3.17) with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and children with obsessive compulsive disorder (OCD), as well as typically developing (TD) children. Parents completed the Child Behavior Checklist (CBCL), and the children underwent structural MRI at 3 T. FreeSurfer software was used to automatically segment the amygdala subnuclei. A general linear model revealed that children and adolescents with ASD, ADHD, and OCD had higher anxiety scores compared to TD children (p < .001). A subsequent interaction analysis revealed that children with ASD (B = 0.09, p < .0001) and children with OCD (B = 0.1, p < .0001) who had high anxiety had larger right central nuclei volumes compared with TD children. Similar results were obtained for the right anterior amygdaloid area. Amygdala subnuclei volumes may be key to identifying children with neurodevelopmental disorders or those with OCD who are at high risk for anxiety. Findings may inform the development of targeted behavioral interventions to address anxiety behaviors and to assess the downstream effects of such interventions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Attention Deficit Disorder with Hyperactivity / Autism Spectrum Disorder / Obsessive-Compulsive Disorder Type of study: Prognostic_studies Limits: Adolescent / Adult / Child / Humans Language: En Journal: Hum Brain Mapp Journal subject: CEREBRO Year: 2022 Document type: Article Affiliation country: Canadá Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Attention Deficit Disorder with Hyperactivity / Autism Spectrum Disorder / Obsessive-Compulsive Disorder Type of study: Prognostic_studies Limits: Adolescent / Adult / Child / Humans Language: En Journal: Hum Brain Mapp Journal subject: CEREBRO Year: 2022 Document type: Article Affiliation country: Canadá Country of publication: Estados Unidos