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Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH.
Gart, Eveline; van Duyvenvoorde, Wim; Caspers, Martien P M; van Trigt, Nikki; Snabel, Jessica; Menke, Aswin; Keijer, Jaap; Salic, Kanita; Morrison, Martine C; Kleemann, Robert.
Affiliation
  • Gart E; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
  • van Duyvenvoorde W; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.
  • Caspers MPM; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
  • van Trigt N; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Zeist, the Netherlands.
  • Snabel J; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
  • Menke A; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
  • Keijer J; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
  • Salic K; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.
  • Morrison MC; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
  • Kleemann R; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
FASEB J ; 36(8): e22435, 2022 08.
Article in En | MEDLINE | ID: mdl-35830259
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / Hyperinsulinism Type of study: Risk_factors_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2022 Document type: Article Affiliation country: Países Bajos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / Hyperinsulinism Type of study: Risk_factors_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2022 Document type: Article Affiliation country: Países Bajos Country of publication: Estados Unidos