Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological materials: An updated review.
J Pharm Biomed Anal
; 219: 114921, 2022 Sep 20.
Article
in En
| MEDLINE
| ID: mdl-35839579
ABSTRACT
Although almost 60 years have passed since their first application, bisphosphonates are still in use as medicine against osteoporosis. Due to their chemical structures and properties, these compounds have attracted the attention of many scientists. From an analytical point of view, various analytical methods have been published in the last decade for the determination of these drugs involving separation techniques (HPLC, GC, CE), electrochemical, sensors, spectrophotometry, IR, etc. The present article is a continuation of the 2008 review article of the authors on the analysis of bisphosphonates (C.K. Zacharis, P.D. Tzanavaras, JPBA 48 (2008) 483-496) and it focuses on bioanalytical and pharmaceutical QC applications on the analysis of this class of pharmaceutically active compounds presenting a critical discussion on advantages/disadvantages, figures of merit and analytical features of techniques and methods on this topic.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoporosis
/
Diphosphonates
Limits:
Humans
Language:
En
Journal:
J Pharm Biomed Anal
Year:
2022
Document type:
Article
Affiliation country:
Grecia