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Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies.
Alford, Joshua S; Lampe, John W; Brach, Dorothy; Chesworth, Richard; Cosmopoulos, Kat; Duncan, Kenneth W; Eckley, Sean T; Kutok, Jeffrey L; Raimondi, Alejandra; Riera, Thomas V; Shook, Brian; Tang, Cuyue; Totman, Jennifer; Farrow, Neil A.
Affiliation
  • Alford JS; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Lampe JW; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Brach D; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Chesworth R; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Cosmopoulos K; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Duncan KW; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Eckley ST; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Kutok JL; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Raimondi A; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Riera TV; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Shook B; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Tang C; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Totman J; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
  • Farrow NA; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.
ACS Med Chem Lett ; 13(7): 1137-1143, 2022 Jul 14.
Article in En | MEDLINE | ID: mdl-35859865
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos