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The impact of the covalently closed circular DNA level on recurrence of hepatocellular carcinoma after initial hepatectomy: an analysis of patients with resolved hepatitis B virus infection.
Bae, Sung Kwan; Arita, Junichi; Akamatsu, Nobuhisa; Maki, Harufumi; Nishioka, Yujiro; Kawahara, Takuya; Miyata, Akinori; Kokudo, Takashi; Nagata, Rihito; Mihara, Yuichiro; Ichida, Akihiko; Inagaki, Yoshinori; Kawaguchi, Yoshikuni; Ishizawa, Takeaki; Kaneko, Junichi; Tamura, Sumihito; Tanaka, Yasuhito; Moriya, Kyoji; Hasegawa, Kiyoshi.
Affiliation
  • Bae SK; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Arita J; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Akamatsu N; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Maki H; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Nishioka Y; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Kawahara T; Biostatistics Unit, Clinical Research Promotion Center, University of Tokyo Hospital, Tokyo, Japan.
  • Miyata A; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Kokudo T; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Nagata R; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Mihara Y; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Ichida A; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Inagaki Y; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Kawaguchi Y; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Ishizawa T; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Kaneko J; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Tamura S; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Tanaka Y; Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
  • Moriya K; Department of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan.
  • Hasegawa K; Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan. Electronic address: kihase-tky@umin.ac.jp.
HPB (Oxford) ; 24(10): 1780-1788, 2022 10.
Article in En | MEDLINE | ID: mdl-35863998
ABSTRACT

BACKGROUND:

We assessed whether or not covalently closed circular DNA (cccDNA) levels in the background liver influence the recurrence of hepatocellular carcinoma (HCC) in patients with resolved hepatitis B virus (HBV) infection.

METHODS:

Among 425 patients who underwent initial hepatectomy for HCC between 2010 and 2018, a retrospective review was performed in 44 with resolved HBV infection. The clinicopathologic characteristics were analyzed for correlation with tumor recurrence. The HBV cccDNA levels were tested via a droplet digital polymerase chain reaction assay.

RESULTS:

HBV cccDNA was detected in 27 of 44 patients (61%), and the median level was 1.0 copies/1000 ng (range, 0-931.3 copies/1000 ng). Anti-HBc ≥8.9 S/CO was associated with cccDNA detection (odds ratio, 11.08; 95% confidence interval [95% CI], 2.48-49.46; P = 0.002). Twenty-eight patients (64%) developed HCC recurrence after hepatectomy. The overall 3- and 5-year recurrence-free survival rates were 45.7% and 34.3%, respectively.19 HBV cccDNA levels was not significantly associated with HCC recurrence, while the presence of multiple tumors was an independent risk fact or (hazard ratio, 6.53; 95% CI, 2.48-17.19; P < 0.001.

CONCLUSION:

HBV cccDNA levels did not influence HCC recurrence after hepatectomy. Anti-HBc levels may be used as a surrogate marker for cccDNA.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Hepatitis B / Liver Neoplasms Type of study: Diagnostic_studies Limits: Humans Language: En Journal: HPB (Oxford) Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Japón
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Hepatitis B / Liver Neoplasms Type of study: Diagnostic_studies Limits: Humans Language: En Journal: HPB (Oxford) Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Japón