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Assessing the Morphological and Behavioral Toxicity of Catechol Using Larval Zebrafish.
Morash, Michael G; Soanes, Kelly H; Achenbach, John C; Ellis, Lee D.
Affiliation
  • Morash MG; Aquatic Crop and Resource Development, National Research Council of Canada, Halifax, NS B3H 3Z1, Canada.
  • Soanes KH; Aquatic Crop and Resource Development, National Research Council of Canada, Saskatoon, SK S7N 0W9, Canada.
  • Achenbach JC; Aquatic Crop and Resource Development, National Research Council of Canada, Halifax, NS B3H 3Z1, Canada.
  • Ellis LD; Aquatic Crop and Resource Development, National Research Council of Canada, Halifax, NS B3H 3Z1, Canada.
Int J Mol Sci ; 23(14)2022 Jul 20.
Article in En | MEDLINE | ID: mdl-35887331
Catechol is a ubiquitous chemical used in the manufacturing of fragrances, pharmaceuticals and flavorants. Environmental exposure occurs in a variety of ways through industrial processes, during pyrolysis and in effluent, yet despite its prevalence, there is limited information regarding its toxicity. While the genotoxicity and gastric carcinogenicity of catechol have been described in depth, toxicological studies have potentially overlooked a number of other effects relevant to humans. Here, we have made use of a general and behavioral larval zebrafish toxicity assay to describe previously unknown catechol-based toxicological phenomena. Behavioral testing revealed catechol-induced hypoactivity at concentrations an order of magnitude lower than observable endpoints. Catechol exposure also resulted in punctate melanocytes with concomitant decreases in the expression of pigment production and regulation markers mitfa, mc1r and tyr. Because catechol is converted into a number of toxic metabolites by tyrosinase, an enzyme found almost exclusively in melanocytes, an evaluation of the effects of catechol on these cells is critical to evaluating the safety of this chemical. This work provides insights into the toxic nature of catechol and highlights the benefits of the zebrafish larval testing platform in being able to dissect multiple aspects of toxicity with one model.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water Pollutants, Chemical / Zebrafish Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Canadá Country of publication: Suiza

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water Pollutants, Chemical / Zebrafish Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Canadá Country of publication: Suiza