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Last-step 18F-fluorination of supported 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazole conjugates for applications in positron emission tomography.
Steffann, Marine; Tisseraud, Marion; Bluet, Guillaume; Roy, Sebastien; Aubert, Catherine; Fouquet, Eric; Hermange, Philippe.
Affiliation
  • Steffann M; Univ. Bordeaux, Institut des Sciences Moléculaires, UMR-CNRS 5255, 351 Cours de la Libération, 33405, Talence Cedex, France. philippe.hermange@u-bordeaux.fr.
  • Tisseraud M; Sanofi, Integrated Drug Discovery (IDD) Isotope Chemistry (IC), 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France.
  • Bluet G; Univ. Bordeaux, Institut des Sciences Moléculaires, UMR-CNRS 5255, 351 Cours de la Libération, 33405, Talence Cedex, France. philippe.hermange@u-bordeaux.fr.
  • Roy S; Sanofi, Integrated Drug Discovery (IDD) Isotope Chemistry (IC), 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France.
  • Aubert C; Sanofi, Integrated Drug Discovery (IDD) Isotope Chemistry (IC), 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France.
  • Fouquet E; Sanofi, Integrated Drug Discovery (IDD) Isotope Chemistry (IC), 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France.
  • Hermange P; Univ. Bordeaux, Institut des Sciences Moléculaires, UMR-CNRS 5255, 351 Cours de la Libération, 33405, Talence Cedex, France. philippe.hermange@u-bordeaux.fr.
Chem Commun (Camb) ; 58(65): 9140-9143, 2022 Aug 11.
Article in En | MEDLINE | ID: mdl-35894218
ABSTRACT
Aiming for potential applications in positron emission tomography, fully automated productions of 18F-labelled bioconjugates were achieved using heterogenous precursors obtained by anchoring imidazole-di-tert-butyl-arylsilanes to a polystyrene resin. The reactions were performed using either "batch" or "flow" procedures, avoiding both the time-consuming azeotropic drying and HPLC purifications usually required.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Positron-Emission Tomography / Halogenation Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Francia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Positron-Emission Tomography / Halogenation Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Francia