pH-Responsive Self-Assembled Compartments as Tuneable Model Protocellular Membrane Systems.
Chembiochem
; 23(24): e202200371, 2022 12 16.
Article
in En
| MEDLINE
| ID: mdl-35968882
ABSTRACT
Prebiotically plausible single-chain amphiphiles are enticing as model protocellular compartments to study the emergence of cellular life, owing to their self-assembling properties. Here, we investigated the self-assembly behaviour of mono-N-dodecyl phosphate (DDP) and mixed systems of DDP with 1-dodecanol (DDOH) at varying pH conditions. Membranes composed of DDP showed pH-responsive vesicle formation in a wide range of pH with a low critical bilayer concentration (CBC). Further, the addition of DDOH to DDP membrane system enhanced vesicle formation and stability in alkaline pH regimes. We also compared the high-temperature behaviour of DDP and DDPDDOH membranes with conventional fatty acid membranes. Both, DDP and DDPDDOH mixed membranes possess packing that is similar to decanoic acid membrane. However, the micropolarity of these systems is similar to phospholipid membranes. Finally, the pH-dependent modulation of different phospholipid membranes doped with DDP was also demonstrated to engineer tuneable membranes with potential translational implications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphates
/
Models, Biological
Language:
En
Journal:
Chembiochem
Journal subject:
BIOQUIMICA
Year:
2022
Document type:
Article
Affiliation country:
India