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Maillard Reaction Products with Anti-Tobacco Mosaic Virus Activities Generated in Processed Thermopsis lanceolata R. Br. Seed Extract.
Hu, Zhan-Xing; Zhang, Peng; Zou, Ji-Bin; An, Qiao; Yi, Ping; Yuan, Chun-Mao; Yang, Jue; Gu, Wei; Huang, Lie-Jun; Zhao, Li-Hua; Hao, Xiao-Jiang.
Affiliation
  • Hu ZX; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
  • Zhang P; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
  • Zou JB; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
  • An Q; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, PR China.
  • Yi P; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
  • Yuan CM; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
  • Yang J; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
  • Gu W; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
  • Huang LJ; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
  • Zhao LH; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
  • Hao XJ; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
J Org Chem ; 87(17): 11309-11318, 2022 09 02.
Article in En | MEDLINE | ID: mdl-35981284
ABSTRACT
Six novel Maillard reaction products (MRPs) (1-6) were isolated from the processed Thermopsis lanceolata R. Br. seed extract, along with one biogenetically related intermediate (7). Compounds 1-4 possessed three rare dimerization patterns constructed by cytisine, whereas compounds 5 and 6 represented the first example of the addition products of cytisine and 5,6-dihydroxy-4-hexanolide. Their structures were elucidated by comprehensive spectroscopic data analysis and quantum chemistry calculations including GIAO 13C{1H} NMR and ECD calculation, combined with single-crystal X-ray diffraction analysis. Biologically, compound 3 displayed significant anti-tobacco mosaic virus activity compared with the positive control ningnanmycin.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tobacco Mosaic Virus Language: En Journal: J Org Chem Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tobacco Mosaic Virus Language: En Journal: J Org Chem Year: 2022 Document type: Article