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Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling.
Yuan, Chuang; Ai, Kelong; Xiang, Menghua; Xie, Chengliang; Zhao, Mingyi; Wu, Ming; Li, Hongli; Wu, Yueren; Cao, Yueqing; Li, Can; Zhong, Yanjun; Pei, Xiaomeng; Law, Helen Ka Wai; Gao, Liqian; Xiao, Qicai; Yang, Xinyu.
Affiliation
  • Yuan C; Department of Hematology, Xiangya Hospital, Central South University, Changsha, 410000, PR China.
  • Ai K; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410000, PR China.
  • Xiang M; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410000, PR China.
  • Xie C; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, and Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, PR China.
  • Zhao M; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, and Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, PR China.
  • Wu M; Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, PR China.
  • Li H; Department of Hematology, Xiangya Hospital, Central South University, Changsha, 410000, PR China.
  • Wu Y; Department of Hematology, Xiangya Hospital, Central South University, Changsha, 410000, PR China.
  • Cao Y; Department of Hematology, Xiangya Hospital, Central South University, Changsha, 410000, PR China.
  • Li C; Department of Hematology, Xiangya Hospital, Central South University, Changsha, 410000, PR China.
  • Zhong Y; Department of Hematology, Xiangya Hospital, Central South University, Changsha, 410000, PR China.
  • Pei X; ICU Center in the Second Xiangya Hospital, Central South University, Changsha, 410000, PR China.
  • Law HKW; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, PR China.
  • Gao L; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, PR China.
  • Xiao Q; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, and Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, PR China.
  • Yang X; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, and Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, PR China. xiaoqicai@mail.sysu.edu.cn.
Cell Death Dis ; 13(8): 722, 2022 08 18.
Article in En | MEDLINE | ID: mdl-35982051
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Promethazine / Lipopolysaccharides / Sepsis Limits: Animals / Humans Language: En Journal: Cell Death Dis Year: 2022 Document type: Article Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Promethazine / Lipopolysaccharides / Sepsis Limits: Animals / Humans Language: En Journal: Cell Death Dis Year: 2022 Document type: Article Country of publication: Reino Unido