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PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120.
Fazio, Grazia; Bresolin, Silvia; Silvestri, Daniela; Quadri, Manuel; Saitta, Claudia; Vendramini, Elena; Buldini, Barbara; Palmi, Chiara; Bardini, Michela; Grioni, Andrea; Rigamonti, Silvia; Galbiati, Marta; Mecca, Stefano; Savino, Angela Maria; Peloso, Alberto; Tu, Jia-Wey; Bhatia, Sanil; Borkhardt, Arndt; Micalizzi, Concetta; Lo Nigro, Luca; Locatelli, Franco; Conter, Valentino; Rizzari, Carmelo; Valsecchi, Maria Grazia; Te Kronnie, Geertruij; Biondi, Andrea; Cazzaniga, Giovanni.
Affiliation
  • Fazio G; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy. Electronic address: grazia.fazio@unimib.it.
  • Bresolin S; Paediatric Haematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University and Hospital, Padua, Italy.
  • Silvestri D; Centre of Biostatistics for Clinical Epidemiology, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
  • Quadri M; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy.
  • Saitta C; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy.
  • Vendramini E; Paediatric Haematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University and Hospital, Padua, Italy.
  • Buldini B; Paediatric Haematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University and Hospital, Padua, Italy.
  • Palmi C; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy.
  • Bardini M; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy.
  • Grioni A; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy.
  • Rigamonti S; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy.
  • Galbiati M; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy.
  • Mecca S; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy.
  • Savino AM; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Peloso A; Paediatric Haematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University and Hospital, Padua, Italy.
  • Tu JW; Department of Paediatric Oncology, Haematology and Clinical Immunology, Heinrich-Heine University Dusseldorf, Medical Faculty, Düsseldorf, Germany.
  • Bhatia S; Department of Paediatric Oncology, Haematology and Clinical Immunology, Heinrich-Heine University Dusseldorf, Medical Faculty, Düsseldorf, Germany.
  • Borkhardt A; Department of Paediatric Oncology, Haematology and Clinical Immunology, Heinrich-Heine University Dusseldorf, Medical Faculty, Düsseldorf, Germany.
  • Micalizzi C; Haematology/Oncology Unit, G. Gaslini Children's Hospital, Genoa, Italy.
  • Lo Nigro L; Center of Paediatric Haematology Oncology, Azienda Ospedaliero-Universitaria "Policlinico Vittorio Emanuele", Catania, Italy.
  • Locatelli F; Department of Paediatric Haematology/Oncology and Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesù, Department of Paediatrics, Sapienza University of Rome, Rome, Italy.
  • Conter V; Paediatrics, University of Milano Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy.
  • Rizzari C; Paediatrics, University of Milano Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy.
  • Valsecchi MG; Centre of Biostatistics for Clinical Epidemiology, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
  • Te Kronnie G; Paediatric Haematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University and Hospital, Padua, Italy.
  • Biondi A; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy; Paediatrics, University of Milano Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy.
  • Cazzaniga G; Centro Ricerca M. Tettamanti, Paediatrics, University of Milano Bicocca, Monza, Italy; Medical Genetics, University of Milano Bicocca, School of Medicine and Surgery, Monza, Italy. Electronic address: giovanni.cazzaniga@unimib.it.
EBioMedicine ; 83: 104224, 2022 Sep.
Article in En | MEDLINE | ID: mdl-35985167
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limits: Child / Humans Language: En Journal: EBioMedicine Year: 2022 Document type: Article Country of publication: Países Bajos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limits: Child / Humans Language: En Journal: EBioMedicine Year: 2022 Document type: Article Country of publication: Países Bajos