Seizure control in successive pregnancies in Australian women with epilepsy.
Acta Neurol Scand
; 146(5): 610-614, 2022 Nov.
Article
in En
| MEDLINE
| ID: mdl-35986483
ABSTRACT
OBJECTIVES:
To investigate control of epileptic seizures during pairs of successive pregnancies in antiseizure medication (ASM)-treated women with epilepsy. MATERIALS ANDMETHODS:
Analysis of seizure freedom rates during 436 pairs of successive pregnancies in Australian women with epilepsy, in nearly all instances long-standing epilepsy.RESULT:
There was a higher rate of seizure-free second pregnancies compared with first paired pregnancies (63.1% vs. 51.4%; Relative Risk (R.R.) = 1.2277; 95% CI 1.0930, 1.3789) and of seizure-free pre-pregnancy years before second as compared with first paired pregnancies in the same women (63.6% vs. 52.4%; R.R. = 1.2616; 95% CI 1.1337, 1.4040). In 108 women whose ASM therapy was unaltered throughout both of their pregnancies, the seizure-freedom rate was higher in the second of the paired pregnancies (82.4% vs. 69.4%; R.R. = 1.1867, 95% CI 1.0189, 1.3821).CONCLUSIONS:
Altered ASM therapy after the first of a pair of successive pregnancies did not fully account for the better overall seizure control in the corresponding second pregnancies. Some additional factor may have been in operation, possibly a greater preparedness to undertake a further pregnancy if seizures were already fully controlled.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications
/
Epilepsy
Type of study:
Etiology_studies
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Oceania
Language:
En
Journal:
Acta Neurol Scand
Year:
2022
Document type:
Article
Affiliation country:
Australia