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Mitapivat in adult patients with pyruvate kinase deficiency receiving regular transfusions (ACTIVATE-T): a multicentre, open-label, single-arm, phase 3 trial.
Glenthøj, Andreas; van Beers, Eduard J; Al-Samkari, Hanny; Viprakasit, Vip; Kuo, Kevin H M; Galactéros, Frédéric; Chonat, Satheesh; Porter, John; Zagadailov, Erin; Xu, Rengyi; Oluyadi, Abdulafeez; Hawkins, Peter; Gheuens, Sarah; Beynon, Vanessa; Barcellini, Wilma.
Affiliation
  • Glenthøj A; Department of Haematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. Electronic address: andreas.glenthoej@regionh.dk.
  • van Beers EJ; Benign Hematology Center, Van Creveldkliniek, University Medical Center Utrecht, University Utrecht, Utrecht, the Netherlands.
  • Al-Samkari H; Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Viprakasit V; Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Kuo KHM; Division of Hematology, University of Toronto, Toronto, ON, Canada.
  • Galactéros F; Unité des Maladies Génétiques du Globule Rouge, CHU Henri Mondor, Créteil, France.
  • Chonat S; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA, USA.
  • Porter J; Department of Haematology, University College London Cancer Institute, London, UK.
  • Zagadailov E; Agios Pharmaceuticals, Cambridge, MA, USA.
  • Xu R; Agios Pharmaceuticals, Cambridge, MA, USA.
  • Oluyadi A; Agios Pharmaceuticals, Cambridge, MA, USA.
  • Hawkins P; Agios Pharmaceuticals, Cambridge, MA, USA.
  • Gheuens S; Agios Pharmaceuticals, Cambridge, MA, USA.
  • Beynon V; Agios Pharmaceuticals, Cambridge, MA, USA.
  • Barcellini W; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Lancet Haematol ; 9(10): e724-e732, 2022 Oct.
Article in En | MEDLINE | ID: mdl-35988546
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvate Kinase / Hemoglobins Type of study: Clinical_trials Limits: Adolescent / Adult / Female / Humans / Male Language: En Journal: Lancet Haematol Year: 2022 Document type: Article Country of publication: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvate Kinase / Hemoglobins Type of study: Clinical_trials Limits: Adolescent / Adult / Female / Humans / Male Language: En Journal: Lancet Haematol Year: 2022 Document type: Article Country of publication: Reino Unido