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Transcriptional Behavior of Regulatory T Cells Predicts IBD Patient Responses to Vedolizumab Therapy.
Abreu, Maria T; Davies, Julie M; Quintero, Maria A; Delmas, Amber; Diaz, Sophia; Martinez, Catherine D; Venables, Thomas; Reich, Adrian; Crynen, Gogce; Deshpande, Amar R; Kerman, David H; Damas, Oriana M; Fernandez, Irina; Santander, Ana M; Pignac-Kobinger, Judith; Burgueno, Juan F; Sundrud, Mark S.
Affiliation
  • Abreu MT; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Davies JM; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Quintero MA; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Delmas A; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
  • Diaz S; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Martinez CD; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
  • Venables T; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
  • Reich A; Center for Computational Biology and Bioinformatics, The Scripps Research Institute, Jupiter, Florida, USA.
  • Crynen G; Center for Computational Biology and Bioinformatics, The Scripps Research Institute, Jupiter, Florida, USA.
  • Deshpande AR; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Kerman DH; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Damas OM; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Fernandez I; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Santander AM; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Pignac-Kobinger J; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Burgueno JF; Division of Gastroenterology and Hepatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Sundrud MS; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Inflamm Bowel Dis ; 28(12): 1800-1812, 2022 12 01.
Article in En | MEDLINE | ID: mdl-35993552
Vedolizumab (VDZ) is effective in the treatment of IBD. Immunophenotyping and RNAseq of T cells were used to inform its mechanism of action. Changes in T regulatory cells in the periphery and mucosa have the greatest relationship to VDZ response.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Colitis, Ulcerative / Crohn Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Colitis, Ulcerative / Crohn Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Estados Unidos