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The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells.
Kurimchak, Alison M; Herrera-Montávez, Carlos; Montserrat-Sangrà, Sara; Araiza-Olivera, Daniela; Hu, Jianping; Neumann-Domer, Ryan; Kuruvilla, Mathew; Bellacosa, Alfonso; Testa, Joseph R; Jin, Jian; Duncan, James S.
Affiliation
  • Kurimchak AM; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Herrera-Montávez C; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Montserrat-Sangrà S; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Araiza-Olivera D; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Hu J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Neumann-Domer R; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Kuruvilla M; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Bellacosa A; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Testa JR; Biomedical Sciences Graduate Program, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
  • Jin J; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Duncan JS; Biomedical Sciences Graduate Program, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Sci Signal ; 15(749): eabn2707, 2022 08 30.
Article in En | MEDLINE | ID: mdl-36041010
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos