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Rare genetic variant burden in DPYD predicts severe fluoropyrimidine-related toxicity risk.
De Mattia, Elena; Silvestri, Marco; Polesel, Jerry; Ecca, Fabrizio; Mezzalira, Silvia; Scarabel, Lucia; Zhou, Yitian; Roncato, Rossana; Lauschke, Volker M; Calza, Stefano; Spina, Michele; Puglisi, Fabio; Toffoli, Giuseppe; Cecchin, Erika.
Affiliation
  • De Mattia E; Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini n. 2, 33081 Aviano PN, Italy. Electronic address: edemattia@cro.it.
  • Silvestri M; Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Department of Applied Research and Technological Development, Via Giacomo Venezian 1, 20133 Milano, Italy. Electronic address: marco.silvestri@istitutotumori.mi.it.
  • Polesel J; Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini n. 2, 33081 Aviano PN, Italy. Electronic address: polesel@cro.it.
  • Ecca F; Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini n. 2, 33081 Aviano PN, Italy. Electronic address: ecca.fabrizio@gmail.com.
  • Mezzalira S; Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini n. 2, 33081 Aviano PN, Italy. Electronic address: silvia.mezzalira.23@gmail.com.
  • Scarabel L; Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini n. 2, 33081 Aviano PN, Italy. Electronic address: lucia.scarabel@cro.it.
  • Zhou Y; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: yitian.zhou@ki.se.
  • Roncato R; Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini n. 2, 33081 Aviano PN, Italy. Electronic address: rroncato@cro.it.
  • Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstraße 112, 70376 Stuttgart, Germany; University of Tuebingen, Geschwister-Scholl-Platz, 72074 Tuebingen, Germany. Electronic address: vo
  • Calza S; University of Brescia, Department of Molecular and Translational Medicine, Viale Europa 11, 25123 Brescia, Italy. Electronic address: stefano.calza@unibs.it.
  • Spina M; Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCSS, via Franco Gallini n. 2, 33081 Aviano PN, Italy. Electronic address: mspina@cro.it.
  • Puglisi F; Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCSS, via Franco Gallini n. 2, 33081 Aviano PN, Italy; Department of Medicine, University of Udine, Via delle Scienze, 206, 33100 Udine UD, Italy. Electronic address: fabio.puglisi@cro.it.
  • Toffoli G; Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini n. 2, 33081 Aviano PN, Italy. Electronic address: gtoffoli@cro.it.
  • Cecchin E; Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini n. 2, 33081 Aviano PN, Italy. Electronic address: ececchin@cro.it.
Biomed Pharmacother ; 154: 113644, 2022 Oct.
Article in En | MEDLINE | ID: mdl-36063648
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quality of Life / Dihydrouracil Dehydrogenase (NADP) Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Aspects: Patient_preference Limits: Humans Language: En Journal: Biomed Pharmacother Year: 2022 Document type: Article Country of publication: Francia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quality of Life / Dihydrouracil Dehydrogenase (NADP) Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Aspects: Patient_preference Limits: Humans Language: En Journal: Biomed Pharmacother Year: 2022 Document type: Article Country of publication: Francia