Fluorescence probe for selectively monitoring biothiols within cells and mouse depression diagnosis.
Biomed Pharmacother
; 154: 113647, 2022 Oct.
Article
in En
| MEDLINE
| ID: mdl-36067570
ABSTRACT
As a global mental disorder, depression is associated with oxidative stress in the brain. Cysteine, a reductive biothiols, regulates the oxidative situation in many biological events including the stress that occurs in the tissues. Exploring the pathology and physiology of depression is still a challenge and always in an urgent need. Thus, developing a new method that could track Cys level without the interferes from other competing substances is of great importance. Herein, we developed a fluorescence probe that could selectively sensing Cys over other biothiols. Besides, we have demonstrated its desirable performance in cellular applications and mouse brain. This work provides a new method for Cys imaging and understanding pathogenesis of depression. We hope the work described here could be used as a potential chemical approach for the diagnosis of Cys associated diseases in clinical applications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Depression
/
Fluorescent Dyes
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomed Pharmacother
Year:
2022
Document type:
Article