Acetaminophen-induced reduction of NIMA-related kinase 7 expression exacerbates acute liver injury.

Sun, Zhenzhen; Wang, Qian; Sun, Le; Wu, Mengying; Li, Shuzhen; Hua, Hu; Sun, Ying; Ni, Tong; Zhou, Chunlei; Huang, Songming; Zhang, Aihua; Zhang, Yue; Jia, Zhanjun

Sun, Zhenzhen; Wang, Qian; Sun, Le; Wu, Mengying; Li, Shuzhen; Hua, Hu; Sun, Ying; Ni, Tong; Zhou, Chunlei; Huang, Songming; Zhang, Aihua; Zhang, Yue; Jia, Zhanjun.

Affiliation

Sun Z; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Wang Q; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Sun L; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China.
Wu M; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Li S; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Hua H; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China.
Sun Y; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Ni T; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Zhou C; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China.
Huang S; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Zhang A; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Zhang Y; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China.
Jia Z; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.

JHEP Rep ; 4(10): 100545, 2022 Oct.

Article in En | MEDLINE | ID: mdl-36097583

Key words

ALF, acute liver failure; ALI, acute liver injury; ALT, alanine aminotransferase; APAP, acetaminophen; AST, aspartate aminotransferase; Apoptosis; CCK-8, cell counting kit 8; CYP2E1; Ctrl, control; GSH, glutathione; Het, heterozygous; LDH, lactate dehydrogenase; MCP-1, monocyte chemoattractant protein-1; MDA, malondialdehyde; NAPQI, N-acetyl-p-benzoquinone imine; ND1, NADH dehydrogenase 1; NEK7, NIMA-related kinase 7; NLRP3; PI, propidium iodide; ROS, reactive oxygen species; TNF-α, tumour necrosis factor-alpha; TPM, transcripts per kilobase of exon model per million mapped reads; WT, wild-type; cKO mice, conditional knockout mice; iKO mice, inducible knockout mice; si, small interfering

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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: JHEP Rep Year: 2022 Document type: Article Affiliation country: China Country of publication: Países Bajos

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