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Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.
Macabuag, Natsuko; Esmieu, William; Breccia, Perla; Jarvis, Rebecca; Blackaby, Wesley; Lazari, Ovadia; Urbonas, Liudvikas; Eznarriaga, Maria; Williams, Rachel; Strijbosch, Annelieke; Van de Bospoort, Rhea; Matthews, Kim; Clissold, Cole; Ladduwahetty, Tammy; Vater, Huw; Heaphy, Patrick; Stafford, Douglas G; Wang, Hong-Jun; Mangette, John E; McAllister, George; Beaumont, Vahri; Vogt, Thomas F; Wilkinson, Hilary A; Doherty, Elizabeth M; Dominguez, Celia.
Affiliation
  • Macabuag N; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Esmieu W; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Breccia P; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Jarvis R; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Blackaby W; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Lazari O; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Urbonas L; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Eznarriaga M; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Williams R; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Strijbosch A; Charles River, Darwinweg 24, Leiden 2333 CR, The Netherlands.
  • Van de Bospoort R; Charles River, Darwinweg 24, Leiden 2333 CR, The Netherlands.
  • Matthews K; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Clissold C; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Ladduwahetty T; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Vater H; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Heaphy P; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States.
  • Stafford DG; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States.
  • Wang HJ; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States.
  • Mangette JE; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States.
  • McAllister G; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Beaumont V; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Vogt TF; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Wilkinson HA; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Doherty EM; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
  • Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.
J Med Chem ; 65(18): 12445-12459, 2022 09 22.
Article in En | MEDLINE | ID: mdl-36098485
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Huntington Disease / Histone Deacetylases Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Huntington Disease / Histone Deacetylases Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Reino Unido