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Effects of Vitamin D Receptor Genotype on Lipid Profiles and Retinopathy Risk in Type 2 Diabetes Patients: A Pilot Study.
Alhawari, Hussam; Jarrar, Yazun; Abulebdah, Dina; Abaalkhail, Sara J; Alkhalili, Marah; Alkhalili, Sura; Alhawari, Hussein; Momani, Munther; Obeidat, Mohammed N; Fram, Rand K; Salahat, Mohammad A; Lee, Su-Jun.
Affiliation
  • Alhawari H; Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Jarrar Y; Department of Pharmaceutical Science, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
  • Abulebdah D; Department of Pharmaceutical Science, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
  • Abaalkhail SJ; Department of Pharmaceutical Science, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
  • Alkhalili M; Department of Pharmaceutical Science, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
  • Alkhalili S; Department of General Surgery, The University of Jordan Hospital, Amman 11942, Jordan.
  • Alhawari H; Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Momani M; Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Obeidat MN; Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Fram RK; Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Salahat MA; Department of Pharmaceutical Science, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
  • Lee SJ; Department of Pharmacology and Pharmacogenomics Research Center, College of Medicine, Inje University, Busan 50834, Korea.
J Pers Med ; 12(9)2022 Sep 11.
Article in En | MEDLINE | ID: mdl-36143273
Genetic polymorphisms affect lipid profiles and are associated with disease complications. Genetic variants in the vitamin D receptor (VDR) gene are associated with type 2 diabetes mellitus (T2DM). In this study, we investigated the effects of VDR genotypes on the lipid profile and disease complications of T2DM patients in a Jordanian population. Ninety T2DM patients were genotyped for four major functional VDR genetic variants, rs2228570 C > T (FokI), rs7975232 A > C (ApaI), rs731236 T > C (TaqI), and rs1544410 C > T (BsmI), using the polymerase chain reaction−restriction fragment length polymorphism method. Lipid profiles and diabetes complications were analyzed and correlated with VDR genotypes. We found that the VDR rs7975232 and rs1544410 alleles were significantly (p = 0.008−0.04) associated with high-density lipoprotein (HDL) levels and retinopathy among patients. Carriers of the rs7975232 A/A genotype exhibited higher levels (49.68 ± 15.86 mg/dL) of HDL than patients with the A/C (44.73 ± 13.38 mg/dL) and C/C (37.93 ± 9.22 mg/dL) genotypes. Moreover, carriers of the rs1544410 T/T genotype had higher levels of HDL (54.31 ± 16.45 mg/dL) than patients with the C/T (43.57 ± 13.24 mg/dL) and C/C (43.98 ± 13.17 mg/dL) genotypes. T2DM patients who carry the rs7975232 C/C genotype were at higher risk (odds ratio [OR] = 7.88) of developing retinopathy compared with carriers of the rs7975232 C/A and A/A genotypes. In addition, T2DM patients with the rs1544410 C/C genotype had a higher risk (OR = 4.21) of developing retinopathy than patients with the rs1544410 C/T and T/T genotypes. Therefore, we concluded that the VDR rs7975232 and rs1544410 alleles were associated with HDL levels and retinopathy and can be considered as potential genetic biomarkers for the lipid profile and retinopathy complication among T2DM patients in a Jordanian population of Arabic origin. Further studies with larger sample sizes are needed to confirm our findings.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Risk_factors_studies Language: En Journal: J Pers Med Year: 2022 Document type: Article Affiliation country: Jordania Country of publication: Suiza

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Risk_factors_studies Language: En Journal: J Pers Med Year: 2022 Document type: Article Affiliation country: Jordania Country of publication: Suiza