ALT, alanine transaminase; ASBT, apical sodium-dependent bile acid transporter; ASBTi, ASBT inhibitors; AST, aspartate transaminase; Alagille; Apical sodium-dependent bile acid transporter (ASBT); BDL, bile duct ligation; BSEP; Bile salt pool size; CCl4, carbon tetrachloride; CK7, cytokeratin 7; Cholestasis; FRET, Förster resonance energy transfer; G-OCA, glycine-conjugated OCA; HepG2 cell, hepatocarcinoma cell; IBAT; MDR2, multidrug resistance protein 2; NASH, non-alcoholic steatohepatitis; NGM282, non-tumorigenic fibroblast growth factor 19 analogue; NTCP; NTCP, Na+/taurocholate cotransporting polypeptide; NucleoBAS, nuclear Bile Acid Sensor; OCA, obeticholic acid; PBC, primary biliary cholangitis; PFIC; PentaOH, pentahydroxylated; RT-qPCR, real-time quantitative PCR; Renal excretion; T-OCA, taurine-conjugated OCA; TCA, taurocholic acid; TetraOH, tetrahydroxylated; U2OS, osteosarcoma cell; UHPLC-MS, ultrahigh-performance liquid chromatography mass spectrometry; WT, wild-type