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Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety.
Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Poli, Giulio; Alberti, Marta; Passoni, Alice; Gaidano, Valentina; Pippione, Agnese C; Vitale, Nicoletta; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ramondetti, Cristina; Lanno, Alessia; Ferraris, Davide M; Canepa, Barbara; Buccinnà, Barbara; Piccinini, Marco; Rizzi, Menico; Saglio, Giuseppe; Al-Karadaghi, Salam; Boschi, Donatella; Miggiano, Riccardo; Tuccinardi, Tiziano; Lolli, Marco L.
Affiliation
  • Sainas S; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Giorgis M; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Circosta P; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy.
  • Poli G; Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin 10126, Italy.
  • Alberti M; Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa 56126, Italy.
  • Passoni A; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, Novara 28100, Italy.
  • Gaidano V; Laboratory of Mass Spectrometry, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milan 20156, Italy.
  • Pippione AC; Division of Hematology and Cell Therapy, AO Ordine Mauriziano, Largo Filippo Turati, 62, Turin 10128, Italy.
  • Vitale N; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Bonanni D; Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, Turin 10126, Italy.
  • Rolando B; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Cignetti A; Life Science Department, University of Modena, Via Università 4, Modena 41121, Italy.
  • Ramondetti C; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Lanno A; Division of Hematology and Cell Therapy, AO Ordine Mauriziano, Largo Filippo Turati, 62, Turin 10128, Italy.
  • Ferraris DM; Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy.
  • Canepa B; Laboratory of Mass Spectrometry, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milan 20156, Italy.
  • Buccinnà B; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, Novara 28100, Italy.
  • Piccinini M; GEM FORLAB, Via Ing. Comotto 36, Caluso, Turin, 10014, Italy.
  • Rizzi M; Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy.
  • Saglio G; Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy.
  • Al-Karadaghi S; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, Novara 28100, Italy.
  • Boschi D; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy.
  • Miggiano R; Division of Hematology and Cell Therapy, AO Ordine Mauriziano, Largo Filippo Turati, 62, Turin 10128, Italy.
  • Tuccinardi T; Department of Biochemistry and Structural Biology, Lund University, Naturvetarvägen 14, Box 124, Lund 221 00, Sweden.
  • Lolli ML; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
J Med Chem ; 65(19): 12701-12724, 2022 10 13.
Article in En | MEDLINE | ID: mdl-36162075
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Oxidoreductases Acting on CH-CH Group Donors Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Oxidoreductases Acting on CH-CH Group Donors Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos