[Interpretation of systematic review articles and meta-analyses : Clinical trials in trauma surgery and orthopedics]. / Interpretation von systematischen Übersichtsarbeiten und Metaanalysen : Klinische Studien in Unfallchirurgie und Orthopädie.
Unfallchirurgie (Heidelb)
; 125(11): 897-908, 2022 Nov.
Article
in De
| MEDLINE
| ID: mdl-36166082
ABSTRACT
Clinical trials must be planned and interpreted in the context of current best clinical and scientific evidence, undoubtedly provided by systematic reviews and meta-analyses, especially Cochrane Reviews. While many clinicians feel overwhelmed by this complex data source, few visualElements (e.g., the traffic light system of the Cochrane risk of bias [RoB2] tool, forest plots, etc.), together with indices such as the I2 heterogeneity statistic, allow for a quick appraisal of all critical and necessary qualitative and quantitative information. The effectiveness of different treatment options can indirectly be assessed by methodological advancements like network meta-analyses.Point estimates of percentages are insufficient to describe the utility and value of a proposed novel intervention, which, in orthopedic and trauma surgery, often represents a step innovation. 95% confidence intervals and the so-called fragility index are helpful in determining the ultimate patient benefit.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Orthopedics
/
Orthopedic Procedures
Type of study:
Prognostic_studies
/
Qualitative_research
/
Systematic_reviews
Limits:
Humans
Language:
De
Journal:
Unfallchirurgie (Heidelb)
Year:
2022
Document type:
Article