Review of scientific evidence to support recommendations of the full-dose DTaP-IPV vaccination in pre-school age children in Italy.
Expert Rev Vaccines
; 21(12): 1819-1830, 2022 12.
Article
in En
| MEDLINE
| ID: mdl-36178008
ABSTRACT
INTRODUCTION:
Two vaccine formulations are available to prevent diphtheria, tetanus, pertussis, and poliomyelitis the pediatric full-dose (DTaP-IPV) and the reduced dose formulation (dTap-IPV). Different immunization schedules are internationally recommended for the pre-school booster dose. AREAS COVERED International and Italian recommendations, scientific evidence on immunogenicity and safety of DTaP/dTap vaccines to support the full dose as a pre-school booster and Italian vaccination coverage (VC) up to adolescence. EXPERT OPINION The WHO recommends a '3+1' schedule with DTaP vaccine for primary immunization, followed by a pre-school booster with DTaP or dTap vaccine. In Italy, a '2+1' schedule, with no booster in the second year, and a pre-school booster dose are recommended with DTPa-IPV vaccines. Studies showed a non-inferior immunogenicity in dTap vaccinees in pre-school age; nevertheless, the antibody titers were usually greater in children vaccinated with DTaP, while lower frequencies of adverse events were recorded in children receiving dTap. Italian VCs for pre-school and adolescent boosters have not been satisfactory, which further reduced during the COVID-19 period. In Italy, the pre-school booster offers the last chance to receive a full dose of DTaP vaccine, thus, representing the most suitable intervention to provide lasting protection in children.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Haemophilus Vaccines
/
Diphtheria-Tetanus-acellular Pertussis Vaccines
/
COVID-19
Limits:
Adolescent
/
Child
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Child, preschool
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Humans
/
Infant
Language:
En
Journal:
Expert Rev Vaccines
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Italia