Prognostic and clinicopathological significance of nm23-H1 expression in non-small cell lung cancer: A meta-analysis.
Medicine (Baltimore)
; 101(39): e30815, 2022 Sep 30.
Article
in En
| MEDLINE
| ID: mdl-36181032
ABSTRACT
BACKGROUND:
The relationship between the expression of nm23-H1 and the invasion and prognosis of non-small cell lung cancer (NSCLC) is still controversial. Therefore, we conducted a meta-analysis to determine the prognostic value of nm23-H1 in patients with NSCLC. And to explore the relationship between the expression of nm23-H1 and clinicopathological features in patients with NSCLC.METHODS:
Literature search in PubMed, EMBASE, Cochrane Library, CNKI, and WanFang database was performed up to June 14, 2021. Studies on the expression and clinical significance of nm23-H1 in NSCLC were included. According to the inclusion and exclusion criteria, 2 researchers independently screened the literatures, extracted the data, and evaluated the quality. Meta-analysis was performed using RevMan 5.4 software (Nordic Cochran Centre, Copenhagen, Denmark).RESULTS:
Twenty-five studies met our inclusion criteria and were finally included for the analysis, involving 2198 participants. Our meta-analysis revealed that nm23-H1 expression was associated with tumor differentiation (ORâ =â 0.54, 95% CI 0.42-0.70, Pâ <â .00001), TNM stage (ORâ =â 1.70, 95% CI 1.23-2.34, Pâ =â .001), and lymph node status (ORâ =â 0.26, 95% CI, 0.17-0.39, Pâ <â .00001), but have no associate with sex, age, pathological type, and T stages. Additionally, low nm23-H1 expression reduced the 3-year survival rate (ORâ =â 2.74, 95% CI 1.54-4.86, Pâ =â .0006) and 5-year survival rate (ORâ =â 2.78, 95% CI 1.36-5.69, Pâ =â .005).CONCLUSION:
Nm23-H1 can be used as a biomarker to predict tumor invasiveness and evaluate the prognosis of patients with NSCLC.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Non-Small-Cell Lung
/
Lung Neoplasms
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Medicine (Baltimore)
Year:
2022
Document type:
Article
Affiliation country:
China