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P-Glycoprotein-Mediated Pharmacokinetic Interactions Increase Pimozide hERG Channel Inhibition.
Morishita, Hiroki; Perera, Liyanage Manosika Buddhini; Zhang, Xieyi; Mizoi, Kenta; Ito, Masa-Aki; Yano, Kentaro; Ogihara, Takuo.
Affiliation
  • Morishita H; Department of Pharmacy, Saiseikai Maebashi Hospital, 564-1 Kamishinden-machi, Maebashi-shi, Gunma 371-0821, Japan; Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki-shi, Gunma 370-0033, Japan. E
  • Perera LMB; Laboratory of Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki-shi, Gunma 370-0033, Japan.
  • Zhang X; Laboratory of Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki-shi, Gunma 370-0033, Japan.
  • Mizoi K; Laboratory of Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki-shi, Gunma 370-0033, Japan.
  • Ito MA; Laboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki-shi, Gunma 370-0033, Japan.
  • Yano K; Laboratory of Drug Metabolism and Pharmacokinetics, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
  • Ogihara T; Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki-shi, Gunma 370-0033, Japan; Laboratory of Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, T
J Pharm Sci ; 111(12): 3411-3416, 2022 12.
Article in En | MEDLINE | ID: mdl-36181876
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pimozide / Antipsychotic Agents Limits: Humans / Male Language: En Journal: J Pharm Sci Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pimozide / Antipsychotic Agents Limits: Humans / Male Language: En Journal: J Pharm Sci Year: 2022 Document type: Article