Acta2/α-SMA, actin, alpha 2, smooth muscle, aorta; BDL, bile duct ligation; BMDMs, bone marrow-derived macrophages; BNIP3; BNIP3, BCL2/adenovirus E1B interacting protein 3; CCl4, carbon tetrachloride; CM, conditional media; ChIP, chromatin immunoprecipitation; Col1a1, collagen, type I, alpha 1; DMXAA, 5,6-dimethylxanthenone-4-acetic acid; ER, endoplasmic reticulum; EtBr, ethidium bromide; HSC, hepatic stellate cell; IRE1α, inositol-requiring enzyme-1α; IRF3, interferon regulatory factor 3; KEGG, Kyoto Encyclopedia of Genes and Genomes; LC3B, microtubule-associated protein 1 light chain 3 beta; LPS, lipopolysaccharide; Liver fibrosis; MCD, methionine/choline-deficient diet; Macrophage; Mitophagy; MnSOD, manganese superoxide dismutase; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; NLRP3, nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3; PBMCs, peripheral blood mononuclear cells; ROS, reactive oxygen species; STING; STING, stimulator of interferon genes; TBK1, TANK binding kinase 1; TGF-ß1, transforming growth factor beta 1; TLR, Toll-like receptor; TNF-α, tumour necrosis factor alpha; Timp1, tissue inhibitor of matrix metalloproteinase 1; WT, wild-type; XBP1; XBP1, X-box binding protein 1; cGAS, cyclic GMP-AMP synthase; mtDNA; mtDNA, mitochondrial DNA; p62, sequestosome 1; sXBP1, spliced XBP1; shRNAs, short hairpin RNAs; uXBP1, unspliced XBP1